Stroke: Molecular Mechanisms and Therapies

Immunometabolism: Molecular Mechanisms, Diseases, and Therapies 2016

Immunometabolism Research Group, Institute of Biomedical Sciences, University of São Paulo (USP), 05508000 São Paulo, SP, Brazil Exercise and Immunometabolism Research Group, Department of Physical Education, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, B...

Immunometabolism: Molecular Mechanisms, Diseases, and Therapies

1 Immunometabolism Research Group, Institute of Biomedical Sciences, University of São Paulo (USP), 05508-000 São Paulo, SP, Brazil 2 Exercise and Immunometabolism Research Group, Department of Physical Education, Universidade Estadual Paulista (UNESP), 19060-900 Presidente Prudente, SP, Brazil 3 Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo ...

Sickle Cell Disease: Genetics, Cellular and Molecular Mechanisms, and Therapies

Sickle cell disease (SCD) is a global public health disorder that affects millions of people across the globe. It is a monogenic disorder caused by an A-toT point mutation in the β-globin gene that produces abnormal hemoglobin S (Hb S), which polymerizes in the deoxygenated state, resulting in physical deformation or sickling of erythrocytes. Sickle erythrocytes promote vaso-occlusion and hemol...

Usher Syndrome: Genes, Proteins, Models, Molecular Mechanisms, and Therapies

Gastrointestinal Stromal Tumors: Molecular Mechanisms and Targeted Therapies

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract and are diverse not only in their clinical behavior but also in their histologic appearance. GISTs are insensitive to conventional sarcoma chemotherapy and radiation. However GISTs are sensitive to small-molecule tyrosine kinase inhibitors as 85-90% of GISTs have KIT or platelet-deriv...